10^th European Chemistry Congress July 15-16, 2020 Vienna, Austria

Biography:

Dina A.El Mously is an assistant lecturer in the Analytical Chemistry Department at Faculty of Pharmacy, Cairo University where she also received her MSc degree in Analytical Chemistry. She is a phD student and her research interests are focused on application of different analytical techniques including ion selective electrodes and chromatography for various pharmaceutical and biological applications.

Abstract:

The microfabricated potentiometric electrodes have been used in the field of medicine and biological science in the last few decades due to their cost effectiveness and easy processing.  Our scientific motivation is to develop a novel and affordable copper (Cu) based microfabricated electrode for various pharmaceutical and biological applications owing to the fact that the currently used sensors are costly to microfabricate which prevent their extensive use. The suggested sensors use a new low cost copper material on sensitized printed circuit board (PCB) which is easily fabricated and compatible with the microfabrication processing. In this study, we further introduce the chemically prepared poly (3-octylthiophene) (POT) to be used as a conducting polymer between the Cu microfabricated electrode and the ionophore-doped membrane. The incorporation of POT provides more stability to the electrical signal due it its hydrophobic nature which prevent the formation of water layer between the solid contact and the membrane. In addition, the dynamic response time was obviously decreased to 3s due to the fast transduction with a reduced potential drift of 1 mV h^-1 . Furthermore, ionophore screening has been performed using calix[6]arene and calix[4]arene to enhance the membrane selectivity towards ^­­neostigmine (NEO) as a model drug analyte.  The proposed sensors showed good sensitivity and selectivity towards NEO in the presence of interfering ions.  

Biography:

Professor of Chemistry at Sikkim Government College (NBBDC),Gangtok, Sikkim, India with 25 years of teaching experience in teaching Undergraduate and Post graduate Chemistry students. Has active research experience of 24 years in synthetic organic chemistry in the field of “Nitrone cycloaddition reactions and their further applications following green chemistry methodologies”. Has established few environment friendly greener methodologies along with atom efficient reactions in the synthesis of few novel isoxazolidine and isoxazoline derivatives using new nitrones via 1,3-dipolar cycloaddition reactions.

Abstract:

Some environment friendly greener methodologies have been described for the synthesis of new isoxazolidine and isoxazoline derivatives using new nitrones via 1,3-dipolar cycloaddition reactions. These also include synthesis of bisisoxazolidine and bisisoxazoline derivatives synthesized from glyoxal and terepthalaldehyde respectively. Few new spiro isoxazolidine derivatives have been also reported using new dipolarophiles. Furthermore, these new isoxazolidine and isoxazoline derivatives are found to have vast synthetic potential as they could be used as precursors for the synthesis of a variety of new organic molecules including peptides, 1,3-amino alcohols with potential biological activities. For the synthesis of peptides, it has been observed that CDMT (chloro dimethyl triazine) has found to be better coupling reagent than conventional DCC (dicyclohexyl carbodiamide) due to the formation of insoluble by-product (N,N-dicyclohexylurea) and purification becomes tedious.. The new nitrones reported are synthesized from furfural, dihydropyran, chlorohydrin, glyoxal, terepthalaldehyde and formamide respectively. Significant increase in the reaction rates, excellent yields, and high selectivity (diastereo and regioselectivity) are the important features observed in these cycloaddition reactions following greener methodologies. It has been observed that high diastereoselectivity in these cycloaddition reactions have been observed when the reactions are performed in water. Synthesis of aldehydes and ketones with new nitrones in atom efficient reactions are the most attractive features as they have future scopes in these reactions. The side products (enamines) obtained during the synthesis of aldehydes and ketones has been successfully utilized as new dipolarophiles in these cycloaddition reactions for the synthesis of spiro cycloadducts. Potential biological activities including cytotoxicity of the new molecules have made these new syntheses much more attractive and useful as well.

Biography:

Dina A.El Mously is an assistant lecturer in the Analytical Chemistry department at Faculty of Pharmacy, Cairo University where she also received her MSc degree in Analytical Chemistry. She is a Ph.D student and her research interests are focused on application of different analytical techniques including ion selective electrodes and chromatography for various pharmaceutical and biological applications.

Abstract:

The concept of green analytical chemistry prevails due to the increasing environmental pollution. Our aim is to develop sensitive and eco-friendly method which is non hazardous to the environment  by producing minimal waste. In this context, a green HPLC method was applied for the simultaneous determination of amlodipine besylate (AML) and irbesartan (IRB) in pharmaceutical formulation. Separation was carried out using X select cyano analytical column (250 ×4.6 mm, 5µm) using methanol -0.02 M phosphate buffer pH 3.5 (65: 35, by volume) as a mobile phase. The separated peaks were detected at 240 nm at a flow rate 1.0 mL/min. Quantification was done over the concentration ranges of 1-25 μg/mL for AML  and 1-60 μg/mL for IRB. The suggested method was validated with regard to linearity, accuracy and precision according to the International Conference on Harmonization guidelines with good results. It was successfully applied to pharmaceutical formulation without interference from excipients. The proposed method could be used as a safer alternative for routine analysis of the mentioned drugs in quality control laboratories.

Biography:

Prof. Eyad Mallah has completed his PhD at the age of 30 years from Tuebingen University, Germany. I’m currently working as a professor at Faculty of Pharmacy in University of Petra. I have a specific interest in Pharmaceutical organic chemistry and Pharmaceutical analytical chemistry. My degree has provided me with a strong background in all areas of Pharmaceutical Chemistry and I have developed a specific interest in bioequivalence studies since I have worked in this field at (JCPR) bioequivalence center for about 7 years. I’m currently working on development of chromatographic and immunoassay methods for analyzing different pharmaceutical compounds in biological fluids which could be used in bio-studies.

Abstract:

As result of the strongly basic character of heterocyclic carbenes 1, they react with Broenstedt acids and have consequently been used as selective deprotonation reagents. The 2H-imidazolium salts formed by this method are accessible by other routes, alkylation of 2H-imidazoles, cyclization reactions or from the thiones and nitric acid, and may be used as precursors in the synthesis of 1 through deprotonation.

So our current research efforts also continue to focus on design and synthesis of new structures of imidazolium salts. Therefore, Owing the strongly basic character of heterocyclic carbenes reacted with methyl phenyl disulfide to give the corresponding adduct 2 which afford a new synthetic route for 2,3-dihydro-imidazole-2-thione. While the reaction of 1 with bis-methane sulfone was carried out at RT to give the salt 4. 

The above mentioned reactions are outlined in scheme 1, the results confirmed by NMR, mass spectroscopy, elemental analysis and single crystal X-ray diffraction.

Biography:

Iesham alzoubi has completed his PhD at the age of 27 years fromDoctor of Philosophy Degree in Agricultural Mechanization Engineering (University of Tehran – Iran) University and Postdoctoral Studies from School of Surveying Geospatial Engineering-Department of Surveying and Geomatics Engineering, University of Tehran .  Current Job: General commission for scientific Agricultural Research – Damascus – Syria (Mechanical Engineer)  He has published more than 16 papers in reputed journals and has been serving as an editorial board member of repute

Abstract:

Land leveling is one of the most important steps in soil preparation for agricultural and other purposes. . New techniques based on artificial intelligence, such as Artificial Neural Network, integrating Artificial Neural Network and Imperialist Competitive Algorithm (ICA-ANN), or Genetic Algorithms (GA-ANN), or Particle Swarm Optimization (PSO-ANN) have been employed for developing predictive models to estimate the energy related parameters and the results were compared to SPSS and Sensitivity Analysis  results. In this study, several soil properties such as cut/fill volume, compressibility factor, specific gravity, moisture content, slope of the area, sand percent, and swelling index were measured and their effects on energy consumption were investigated. Totally 90 samples were collected from 3 land areas by grid size of 20m×20m. The aim of this work was to develop predictive models based on artificial intelligence techniques to predict the environmental indicators of land leveling . Results of sensitivity analysis illustrated that only three parameters consist of soil density, soil compressibility, and soil cut/fill volume had meaningful effects on energy consumption.  Among the proposed methods, the GA-ANN had the most capability in prediction of the environmental energy parameters. However, for prediction of LE and FE the ANN and ICA-ANN algorithms had better performance. On the other hand, SPSS software had higher R 2 value than Minitab software and sensitivity analysis and in fact close to the ANN values. Keywords: Energy; Imperialist competitive algorithm; Sensitivity analysis; ANN; Land levelling; Environmental indicators.

Biography:

Iesham alzoubi has completed his PhD at the age of 27 years fromDoctor of Philosophy Degree in Agricultural Mechanization Engineering (University of Tehran – Iran) University and Postdoctoral Studies from School of Surveying Geospatial Engineering-Department of Surveying and Geomatics Engineering, University of Tehran .  Current Job: General commission for scientific Agricultural Research – Damascus – Syria (Mechanical Engineer)  He has published more than 16 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

One of the most important steps to prepare soil is land leveling. Land leveling with machines require considerable energy.  To increase the accuracy of the calculations, the point height collected from mapping (50 m × 50 m) insert into the GIS environment. rest of the unknown coordinates were obtained using interpolation and a triangular network model (TIN) was used to determine the exact volume of earthworks. In all methods, the equation of the leveling plate, excavation and embankment volumes and maps of land surface after leveling, separation of excavation and embankment and the energy consumption including power of the machine, fuel and manpower were calculated then different methods were compared. The results showed that the ratio of excavation to embankment based on the methods of minimum least squares, genetic algorithm, linear algorithm for optimizing of the particle motions, the particle motion curve algorithm are equal to 1.26, 1.14, 1.12, and 1.16, respectively. On the other hands, the results showed that the method of the particle motion curve algorithm has been shown a 45% reduction in energy consumption in the leveling operation relative to the method of minimum least squares. The genetic algorithm can reduce energy consumption by 42 percent. Between the models used in the method of genetic algorithm, model No. 1 has been estimated that the largest portion of energy consumption is relevant to the fuel (up to 71.83 percent) and the lowest portion of energy consumption is relevant to the manpower (up to 0.38 percent). Therefore, the present study recommends the model of plate-curve genetic algorithm as the best model.

Biography:

ASM and AGM (Akbari-Sara’s Method and Akbari-Ganji Methods) have been invented mainly by Mohammadreza Akbari (M.R.Akbari) in 2019 and 2014 respectively in order to provide a good service for researchers who are a pioneer in the field of nonlinear differential equations. It is worthy to note that I am really grateful to all those who encouraged me to devise these methods which are highly beneficial for analytical solving coupled nonlinear ODEs ( especially ASM ) in Engineering, basic Sciences and Economic.

Abstract:

In this paper, our aims are accuracy, capabilities and power at solving set of the complex non-linear differential at the reaction chemical . As all experts know most of engineering actual systems behavior in practical are nonlinear process and analytical scrutiny these nonlinear problems are difficult or sometimes impossible.

Our purpose is to enhance the ability of solving the mentioned nonlinear differential equations at chemical engineering and similar issues with a simple and innovative approach which entitled
 

Akbari-Sara's Method’’ or ‘’ASM’’

Introduction and theatrical formulation

Consider a well-mixed continuous stirred tank reactor with the reaction and set of nonlinear differential equations. parameters F(the flow rate), cA0 (the initial molar concentration) , TA0 (the initial temperature),Q (the rate of heat input to the reactor), V(the volume of the reactor), E, ΔH, k0 (the pre- exponential constant reaction), cp and ρ denote the heat capacity and density of the fluid in the reactor)