Day :
- Analytical Chemistry | Advanced Organic and Inorganic Chemistry | Polymer Chemistry | Advanced Medicinal Chemistry | Pharmaceutical Chemistry | Materials Chemistry | Chemical Engineering | Green and Sustainable Chemistry | Nuclear Chemistry | Natural Products Chemistry | Biochemistry
Chair
Reino Laatikainen
University of Eastern Finland, Finland
Co-Chair
Hiromitsu Haba
RIKEN Nishina Center for Accelerator-Based Science, Japan
Session Introduction
Xiaodong Si
Southeast University, China
Title: E-BABE- Influence of the vertical flow velocity component on flow-accelerated corrosion in 90° elbow
Time : 14:20-14:40
Biography:
Xiaodong Si is a PhD candidate at School of Energy and Environment, Southeast University since 2016. He has published more than 17 papers in reputed journals and his current research is mainly focus on flow-accelerated corrosion of the carbon steel piping.
Abstract:
Flow accelerated corrosion (FAC), which causes the fracture of the carbon steel piping in the worst cases, is at present one of the most important subjects in coolant systems of fossil and nuclear power plants. Experimental and numerical studies are conducted to investigate the effects of turbulent parameters on flow-accelerated corrosion (FAC) behaviour of low carbon steel at 90° elbow. The experimental testing of flow-accelerated corrosion behaviour was carried out by the array electrode technique in a circulating loop system. The measurement of electrochemical corrosion test shows that the maximum corrosion current density is located in the extrados side of test section while the minimum value appears at the intrados side, consistent with the typical flow-accelerated corrosion induced failures of turbine plant pipelines and equipment. In addition, the flow behavior inside piping components of the loop system were sufficiently simulated by computational fluid dynamics (CFD) simulation and turbulent parameters were compared with flow-accelerated corrosion rate. With respect to the comparison of the results, the radius direction local velocity component (vr) is in good accordance with the configuration of corrosion current density. Therefore, the present results reveal the radius direction local velocity component is a major parameter for predicting the pipe-wall thinning of the 90° elbow due to flow-accelerated corrosion.
Biography:
Neda Fayyazi was a PhD student from School of Pharmacy in Isfahan Medical University, Iran. She has published more than four papers, two lectures and seven posters in reputed journals and conference. Her PhD project is novel investigation of the drug design, synthesis and biological evaluation multi-target hybrid compounds for malaria disease by different in silico methods and use the structure based assessment and repositioning strategy for identification of the best suitable candidate for anticancer drug design. She works with webserver such as HADDOCK, ZDOCK. She has knowledge about computational and QSAR method, pharmacophore modeling and molecular dynamic science. She worked in pharmaceutical company before in PhD grade and have professional experiences in natural product drug discovery and synthetic raw materials based on hybrid compounds.
Abstract:
Exploring potent compounds is a critical first step in the multi-target drug discovery. The primary mechanism of heme detoxification in malaria parasites is hematin crystallization and the target of the antimalaria compounds. A series of chloroquine analogues were designed using the repositioning approach to develop new anticancer compounds. The fingerprints of the protein ligand interaction and ADMET descriptors are used to build and asses’ model for structure based drug discovery to develop new scaffold based on chloroquine hybrid β-hematin inhibitors. In the present study, 50 novel potent chloroquine hybrid β-hematin inhibitors with their IC50 values were collected, was applied. The model built by partial least square algorithm showed excellent predictive power with the correlation coefficients for calibration and cross validation of r2 = 0.93 and q2 = 0.72. We developed and validated QSAR model in prediction of a newly synthesized series of 4-aminoquinolin hybrids and evaluated for their biological activity as an external test series. These compounds were evaluated for cytotoxic cell lines and β-hematin inhibition. The target compounds exhibited high β-hematin inhibition activity and were 3-9 times more active than the positive control. Furthermore, all compounds exhibited moderate to high cytotoxic activity. Pharmacophore features from 10 derivatives in model were generated with HIP-HOP algorithm then used for structure based virtual screening in commercial databases; leading to the identification of the compound with the best score from ChEMBL was 2016904, previously reported as VEGFR-2 inhibitor. The 11 compounds selected have performed a multi-parameter analysis for the comparison of compounds regarding their correlation between dual potency, target evaluation and predicted ADMET properties for drug development.
A A El-Shafei
Mansoura University, Egypt
Title: Comparison between Sn modified single crystal and preferentially Pt electrodes towards ethanol oxidation in acidic medium
Time : 16:55-17:15
Biography:
A A El-Shafei, Science Doctor (Ph.D.-Chemistry), he became a Full Professor of Physical Chemistry at Mansoura University in October 2001. He got his BSc in chemistry, MSc in Physical Chemistry and Specialist in electro-chemistry, Doctor's Degree (Ph.D.) under channel system program (Bonn University, Germany & Mansoura University, Egypt). He acts as active participants in various electrochemist groups in Germany, Japan, France and USA. In 1994 he has spent six months as a Research Associate at CNRS, France. He got various research fellowships from distinguish scientific organizations such as, AxVH, JSPS and JICA. He got the Arab Fund for Economic and Social Development Research Award in 2006. He got the Prize of Distinction in Chemistry from Mansoura University, 1998/1999. Currently, his researches focus on modified electrodes for fuel cell technology and corrosion inhibition. He has published more than 40 papers in reputed journals and has been serving as an Editorial Board Member and Reviewer of Repute Inetrnational Secientific Journals.
Abstract:
Polycrystalline, preferentially oriented and low-index plane Pt single crystal electrodes modified by submonolayer deposition of Sn have been tested for ethanol oxidation in acidic media using cyclic voltammetry and chronoamperometry. In contrast to spontaneous deposition, forced deposition facilitates the irreversible adsorption of Sn particularly on Pt (110), and allows the study of electrochemical activity of Sn modified Pt with all electrodes understudy. For all substrate planes, Sn adlayer enhance the current greatly by the ethanol oxidation process. The enhancement factor for ethanol oxidation depends on both substrate crystallography and Sn coverage. The optimum coverage was found to vary from 0.2 for Pt (100) to around 0.6 for preferentially oriented t“(100)". Preferentially oriented Sn/Pt"(110)" exhibited the highest enhancement factor towards ethanol oxidation. On the other hand, the lowest tolerance ability was found to be Sn modified Pt (111). This was attributed to the accumulation of acetate species at the electrode surface.
Budanovic Maja
Nanyang Technological University, Singapore
Title: The use of tetrathiafulvalene to improve mercury determination in air borne particulate matter
Time : 16:35-16:55
Biography:
Maja Budanovic is a Doctoral Researcher at Nanyang Technological University in Singapore and because of her remarkable performance during her PhD study and excellent academic records, she was selected as an SINGA (Singapore International Graduate Award) ambassador for A*STAR Agency for Science, Technology and Research. Her research was awarded with the best poster award at the 6th International Conference on Environmental Chemistry and Engineering held during July 24-25, 2017 in Rome, Italy. She has completed her Master’s degree in Analytical and Physical Chemistry and Bachelor’s Degree in Chemistry from the University of Zagreb.
Abstract:
Recent studies emphasizing the harmful effect of mercury (Hg) on the environment have increased the demand for low level mercury analysis towards improvement of global Hg pollution control. Multi-elemental inductively coupled plasma mass spectrometry (ICP-MS) determination of Hg can lack accuracy due to low stability of Hg ions in solutions that are susceptible to adsorption/volatilization with negative or positive bias. In this study, sampling and analysis of airborne Hg in Singapore was carried out using our recently developed ICP-MS method. The determined mercury levels were compared against the pollutant standards index (PSI) from 17 October to 17 November 2018, during which the air quality in west Singapore showed small oscillations from 22-66 and good/moderate conditions. We observed an improvement in accuracy for mercury determination of up to 10 times along with proven selectivity of the method evident due to little to no lithium tetrathiafulvalene carboxylate (LiCTTF) influence on other trace elements (Figure 1). Improved stabilisation of mercury ions resulted in higher precision for ICP-MS measurements with RSD ranging from 1.07 to 4.36. Statistical analysis demonstrated the preservation ability of 10 g mL-1 LiCTTF for both microwave digestion procedure and for external calibration using multi-elemental standard solutions with t-values of <1.5. The results obtained in this study emphasize the utility of LiCTTF in ICP-MS determination of mercury to prevent mercury losses, especially for the low-level mercury analysis required for environmental mercury pollution trend assessment.
Edith Odinaka Ahaka
Eastern Mediterranean University, Turkey
Title: Adsorptive removal of potentially toxic heavy metals by banana peel-derived magnetic adsorbent: Single and multicomponent batch study
Biography:
Edith Odinaka Ahaka is from Eastern Mediterranean University, Turkey.
Abstract:
Transformation of agricultural wastes into low cost adsorbent material has been considered viable and effective in wastewater treatment. Here, the efficiency of calcined banana peel derived magnetic adsorbent was evaluated to remove, copper, mercury and zinc (potentially toxic metals) from simulated wastewater. The magnetic responsive adsorbent samples were characterized before and after adsorption by Fourier Transform Infra-Red (FTIR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Brunauer–Emmett–Teller (BET) while the quantity of heavy metal uptake was determined using UV-Vis spectroscopy. The BET analysis confirmed that the magnetic adsorbent contained heterogeneous meso and micropores responsible for trapping the heavy metal ions and the FTIR results revealed that the carboxylic groups (1722 cm–1) and amine groups (889 cm–1) were responsible for the coordination and removing of the heavy metal ions. The thermodynamic results indicated that the adsorption process was endothermic and the modified isotherm demonstrated that multi-component equilibrium adsorption capacity is lower compared to a single solute system.
Chien Han Chen
National Chung Hsing University, Taiwan
Title: Fully bio-based epoxy thermosets with low-dissipation factor
Time : 15:55-16:15
Biography:
Chien Han Chen has completed his Master Degree in 2016 from Department of Chemical Engineering, National Chung Hsing University, Taiwan and continue his PhD in the Insitute of Polymer Science and Engineering, National Taiwan University, Taiwan. He majors in Polymer Chemistry and Green Chemistry. He has published 14 SCI papers since 2016, mainly focusing on the development of high-Tg, flame-retardant and low-dielectric constant polymeric materials.
Abstract:
Epoxy resins are the most popular materials in the polymer history. However, most epoxy resins were produced from the petrochemical materials. To achieve sustainability, we provide a new strategy to prepare fully-bioased epoxy resins from the esterification of bio-based diacids with eugenol, followed by oxidation of the allyl bonds. Furthermore, the epoxy resins are designed to exhibit both the the active ester and epoxy groups, so they can be thermally cured through the exchange reaction of active ester and epoxy groups. Therefore, no additional curing agents are required to cure the epoxy resins. Through NMR, DSC, reology and FTIR analysis, we confirm that they exhibit self-curing characteristics. The self-cured epoxy thermosets do not contain highly polar secondary alcohol, which is always formed when epoxy resins are cured by multiamine or multiphenol. Therefore, the resulting thermosets exhibit very low dissipation factors (around 0.007 U), which is competitive to any other epoxy thermosets. In short, a strategy for preparing fully bio-based epoxy resins and fully bio-based epoxy thermosets with very low dissipation factors are revealed in this work.
Ching-Hsuan Lin
National Chung Hsing University, Taiwan
Title: Structure-property relationship of vinyl-terminated oligo (2,6-dimethyl-1,4-phenylene ether)s (OPEs): Seeking a OPE with better properties
Time : 15:35-15:55
Biography:
Ching Hsuan Lin has completed his PhD from Department of National Chemical Engineering, Cheng Kung University, Taiwan in 1999. He is a Full Professor of National Chung Hsing University, Taiwan. He has published more than 100 papers in reputed journals and has been serving as a Guest Editor of Polymers.
Abstract:
Vinylbenzyl ether-terminated oligo(2,6-dimethyl-1,4-phenylene ether) (1) has been commercialized by Mitsubishi Gas Chemical in the name of OPE-2St. OPE-2St is used in high-frequency printed circuit board due to its low-dielectric characteristic after curing of vinyl groups. However, there is room for improvement in properties. In this work, we describe the preparation of three new OPEs: vinylbenzoate terminated OPE (2), 3,5-bis(vinylbenzyl ether)benzoate-terminated OPE (3) and 3,5-bis(vinylbenzyl ether)benzyl ether terminated OPE (4) and compare their fundamental material properties to (1). We discuss the effect of the number of vinyl groups (two or four) and the linker (benzyl ether or benzoate) on the properties of OPE thermosets. Through data analyses, we found that the thermoset of (3) shows the highest Tg, the highest modulus, the lowest height of tanδ, the lowest CTE, the highest oxygen permeation resistance, the lowest water absorption, the lowest dielectric constant and the second best level of thermal stability among four OPE thermosets. We also found that the toughness of thermoset of (3) can be significantly enhanced through the copolymerization with epoxy resin HP7200 through the exchange reaction of benzoate and epoxy groups. In short, through properties comparison of four thermosets of (1-4), we demonstrate that (3) shows promising properties compared with the commercial (1).
Rui Zhang
Southeast University, China
Title: E-BABE- Improving the removal of sulfuric acid droplets in the process of limestonegypsum desulfurization
Time : 15:00-15:20
Biography:
Rui Zhang is a PhD candidate at School of Energy and Environment, Southeast University since 2017. Her current research is mainly focus on the control of combustion pollutant.
Abstract:
It is commonly accepted that the sulfuric acid droplets is unfavorable to human health and environment and this issue is concerned widespread. According to the statistics, the main source of sulfuric acid droplets is from power-plant. This paper aims to improve the removal of sulfuric acid droplets during desulfurization. Trays are installed into the desulfurization tower to uniform the distribution of the flue gas and increase the contact time. The results shows that the installation of the tray promotes the removal performance of sulfuric acid droplets. The reduction efficiency increases from 40%-50% to 70%-85% with the installation of tray and the installation of double trays is more effective than single trays. The installation of tray makes the contact of flue gas and desulfurization slurry completely more. Moreover, the initial temperature, humidity and liquid to gas ratio of flue gas also has a significant influence on the removal of sulfuric acid droplets. However, the installation of tray increases the resistance of the desulfurization system.
Hiromitsu Haba
RIKEN Nishina Center for Accelerator-Based Science, Japan
Title: Synthesis and chemistry of new elements at RIKEN
Time : 14:40-15:00
Biography:
Hiromitsu Haba received his PhD from Kanazawa University in 1999. In the following years, he worked at Japan Atomic Energy Institute as Postdoctoral Researcher (1999–2001) and at RIKEN as Special Postdoctoral Researcher (2002–2004), Research Scientist (2004–2006), Senior Research Scientist (2007–2010) and Team Leader (2011–2017). Since 2018, he has been Group Director of RI Application Research Group, Nishina Center for Accelerator-Based Science, RIKEN. In 2001, he was awarded the “Young Scientist Award” of the The Japan Society of Nuclear and Radiochemical Sciences. His scientific interests are nuclear and radiochemistry in general, with one focus on the synthesis and chemistry of superheavy elements.
Abstract:
Since the official approval of four new heavy elements with atomic number Z = 113, 115, 117, and 118 by IUPAC in 2016, the 7th period of the periodic table of the elements has been complete. Element 113 was synthesized in the fusion reaction of 70Zn (Z = 30) on 209Bi (Z = 83) using the Gas-filled Recoil Ion Separator (GARIS) at the RIKEN linear accelerator facility. The name “nihonium” and symbol “Nh” were given for the new element, the first discovered in Asian countries. An attempt to create element 119 is under way through the 248Cm (Z = 96) + 51V (Z = 23) reaction. To study chemical properties of the new elements, we have been developing a novel chemistry setup using GARIS. This system is promising for exploring new frontiers in the superheavy element chemistry. Background radiations from unwanted byproducts are suppressed, high production yields are achieved and new chemical reactions can be investigated. Long-lived isotopes of 261Rf (Z = 104), 262Db (Z = 105), 265Sg (Z = 106), and 266Bh (Z = 107) useful for chemistry studies were produced in the heavy-ion induced reactions on the 248Cm target and their decay properties were investigated in detail. Present status and perspectives of the superheavy element chemistry at RIKEN are also presented.
Reino Laatikainen
University of Eastern Finland, Finland
Title: The new dimensions of Quantum Mechanical Spectral Analysis (QMSA)
Time : 10:55-11:15
Biography:
Reino Laatikainen since late 1980’s he worked as the Professor of Chemistry in University of Kuopio, which now-a-days is a part of University of Eastern Finland (UEF). From 2015 he continued his work as Emeritus Professor, focusing to qQMSA. He has published 125 papers on computerized NMR and Structural Chemistry. A general trend has been his interest in flexible and fuzzy systems, including flexible small molecules, drug molecules, proteins and represented also by the 4D NMR spectral parameter prediction and qQMSA of complex NMR spectra.
Abstract:
The coupled nuclear spins floating in sea of molecular electrons obey the laws of quantum mechanics so that frequencies of complex 1H NMR spectra can be calculated within experimental accuracy from chemical shifts and coupling constants. When the effects of molecular environment are added to the model, even the smallest spectral details can be interpreted. This forms the basics of computerized QMSA, pioneered by the computer programs like LAOCOON and NUMARIT. The potential of quantitative QMSA (qQMSA) has been recently realized and several groups work on novel software tools. The bottleneck of QMSA, that the computation time grow steeply with the size of spin-system is not a serious problem anymore. For example, our ChemAdder software allows simulation of testosterone or urine spectra (with >210 metabolites and >1000 spin-particles) in < 1 sec, on standard desktop and their complete iterative fitting demands typically < 1 min. In this presentation the two examples are discussed. Other topics are the Field Independent Adaptive Spectral Libraries (FIASL), qQMSA of isotopomer 2D HSQC spectra, the multispectral QMSA (simultaneous fitting of different types of spectra like real and imaginary), and the holistic QMSA which takes advantage from prior knowledge about populations and chemical shift variations (a common nuisance) so that the current and accumulated results of analyses are consistent – approaching the case that all the spectra were fitted simultaneously. With novel graphical tools, the analysis of even a large spectral set demands from samples to results (mg/mL), just a few clicks.
Ning Wang
Yantai Institute of Coastal Zone Research - CAS, China
Title: Synthesis of amphiphilic PEG-b-PSf-b-PEG triblock copolymers and its application in separation membranes
Time : 14:00-14:20
Biography:
Ning Wang is an Assistant Professor at the Yantai Coastal Zone Research Institute of the Chinese Academy of Sciences. He graduated from the Institute of Chemisry, Chinese Academy of Sciences in 2012 with a PhD in Polymer Chemistry and Polymer Physics. He has been engaged in synthesis of novel polymer and nanocomposites and their applicaton in wastewater treatment for many years, including synthesis of novel amphiphilic block copolymer polyethylene glycol-block-polysulfone-block-polyethylene glycol and wastewater treatement based on nanocomposites such as clay supporting Au, Ag and Cu with dopamine chemistry, etc. other fields. He has published more than 30 SCI papers.
Abstract:
Recently, ultrafiltration (UF) membranes have faced great challenges including the fine control of membrane surfaces for high filtration performances and antifouling properties in treating complex solution systems. Here, a particular type of amphiphilic block copolymer polyethylene glycol-block-polysulfone-block-polyethylene glycol (PEG-b-PSf-b-PEG) was synthesized through one-pot step-growth polymerization with mPEG [monomethylpoly(ethylene glycol)] as two ends to achieve the mobility of hydrophilic polymer chains. Without any other polymers or additives involved, the PEG-b-PSf-b-PEG triblock copolymer UF membrane was fabricated through the non solvent induced phase separation (NIPS) method. The surface properties and filtration performances of UF membranes were tailored through the self-assembly of PEG-b-PSf-b-PEG triblock copolymers combining the thermal and solvent annealing treatments in water at 90°C for 16 h. The annealed PEG-b-PSf-b-PEG triblock copolymer membrane significantly enhanced its water flux resulting from the increased mean pore size with the improved porosity as well as the decreased skin layer thickness, upon annealing. More importantly, the PEG-b-PSf-b-PEG triblock copolymer membrane surface turned from hydrophobic to hydrophilic on annealing with the PEG enrichment on the surface and exhibited improved protein antifouling performances. Our research opens a new avenue to tailor the membrane structure and surface properties by self-assembly of amphiphilic block copolymers upon thermal and solvent annealing treatments.
Bowei Li
Yantai Institute of Coastal Zone Research - CAS, China
Title: Novel rotational valve controlled paper-based microfluidic chip and its application in environmental and biochemical analysis
Time : 13:40-14:00
Biography:
Bowei Li is an Associate Professor at the Yantai Coastal Zone Research Institute of the Chinese Academy of Sciences. He graduated from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences in 2009 with a PhD in Analytical Chemistry. He was funded by NIH program for Postdoctoral Research the at Florida State University. He has been engaged in microfluidic chip laboratory research for many years, including basic research in chemistry and biology based on microfluidic chip platform and its applications in environmental monitoring, POCT, food safety, etc. other fields. He has published more than 30 SCI papers.
Abstract:
We integrated the moving valve on a paper chip and the control of the fluid is realized by the connection and disconnection between the movable channels through the rotational valves. This method can be used to analyze a variety of environmental pollutants and tumor markers, demonstrating that the platform has good applications for environmental detection and bioanalysis in environmental pollutants. We proposed a new strategy for manipulating capillary driven fluids through a real-time controllable moving valve. The use of movable valves allows control of the movement of the paper path between the different layers, enabling the connection or disconnection of the channels. This fabrication process is very simple, versatile, and can be used on microfluidic paper chips of varying complexity levels. We combined ELISA (enzyme linked immunosorbent assays) with mobile valve paper chip to construct a microfluidic-based colorimetric immunosensor. Relying on the intensity of the color-developing signal, we quantitatively analyzed the concentration of carcinoembryonic antigen (CEA) and achieved good results. 2. Using this new rotational chip platform, we have developed a new type of three-dimensional rotating microfluidic chip that uses fluorescent quantum dots as a substrate and combines the specific recognition effect of molecularly imprinted materials to simultaneously treat two phenolic contaminants (4-NP and TNP) for quasi-deterministic quantitative analysis. The microfluidic paper chip adopts a multi-layer integrated chip structure, and the rotating design increases the detection channel, forming a high-throughput detection, effectively utilizing space, low cost, flexible use, and convenient to the detection process.
Hongxia Liu
Anshan Normal University, China
Title: Reaction mechanism and kinetic properties of IIIB transition metals Fe/Co/Ni and their metal oxides FeO/CoO/NiO for catalytic oxidation of methane to methanol: A reliable calculation strategy
Time : 12:35-12:55
Biography:
Hongxia Liu has completed her PhD at Jilin University in China and Postdoctoral studies from University of Massachusetts. She is the Lecture of Inner Mongolia Normal University, a member of Inner Mongolia Key Laboratory of Green Catalysis. She has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of repute.
Abstract:
The related energy and multi-channel oxidation of methane to methanol reaction potential energy surface under the IIIB transition metal and its oxide catalysts and its dynamic characterization have been investigated with the density functional calculations. The geometries were fully optimized by the B3LYP level. The calculation results show that the transition barriers and the reaction rate constant at 298 K all show oscillation modes, with the increase of atomic number. While the calculated reaction energies (Er/kcal mol-1) and the energy of hyper conjugative interaction (E(2)) are gradually increased. The transition metal dioxide can be treated to form transition metal and oxygen, which can still be used as catalysts for methane oxidation and the generated oxygen can continuously be used as oxidants. We calculated the rate constant of this reaction pathway, the calculated dynamic characterization indicating that the rate constant has the positive temperature dependence. According, to the dynamic results and the energetically intermediates and transition states involved in the dominant paths, the reaction is expected to be occurred the most rapid under the catalysis of transition metal oxides. According to our calculation, the title reaction is exothermic reaction under the catalyst of transition metal oxides and it is a thermodynamically feasible reaction. The theoretical reference data on searching new catalysts to catalytic oxidation of methane will be offered.
Takato Mitsudome
Osaka University Graduate School of Engineering Science, Japan
Title: Design of nano-structured catalysts for environmentally benign and selective molecular transformations
Time : 12:15-12:35
Biography:
Takato Mitsudome received his PhD from Osaka University, after obtaining his PhD he joined the group of Professor Kiyotomi Kaneda and Koichiro Jitsukawa as an Assistant Professor in 2007 in the Graduate School of Engineering Science at Osaka University and was promoted as Associate Professor in 2016. His research interest is to design of nano-structured heterogeneous catalysts for environmentally benign and selective molecular transformations. He has published more than 90 papers in reputed journals.
Abstract:
More efficient catalysts can efficiently transform raw materials, thereby eliminating the use of hazardous substances, reducing waste and increasing energy efficiency. Consequently, a better use of resources, less energy consumption and lower environmental degradation across the entire chemical process can be achieved. We have developed high performance heterogeneous metal nanoparticle catalysts such as metal oxide-supported metal nanoparticles and core-shell metal nanoparticles based on the concept of precise control of cooperative catalysis between metal nanoparticles and metal oxides. In the developed catalysts, the active metal nanoparticles and metal oxide are able to cooperatively activate reactants, leading to unprecedented superior activities, selectivities and durabilities to the traditional catalysts in various important organic reactions, including selective oxidations using O2, chemoselective hydrogenations. The key aspects of these newly developed catalyst systems are the following: High catalytic activities and selectivities under mild reaction conditions, high atom-efficiencies, simple preparations of the catalysts, excellent reusabilities, applicabilities to broad substrate-scope and applicabilities to flow column reactors in scaled-up reactions. Some representative achievements in the development of various green sustainable molecular transformations using these catalysts based on the concept of metal oxide-nanoparticle cooperative catalysis are will be presented.
Jianxin Geng
Beijing University of Chemical Technology, China
Title: Carbon nanomaterials/polymers nanocomposites and electrochemical energy storage
Time : 11:55-12:15
Biography:
Jianxin Geng received his PhD from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CAS), in 2004. After graduation, he joined Beijing University of Chemical Technology as a Lecturer. From 2005 to 2011, he worked as Postdoc and Research Assistant Professor at Korea Advanced Institute of Science and Technology, Western Kentucky University and the University of Texas at Austin. In 2011, he joined Technical Institute of Physics and Chemistry, CAS, as Associate Professor and promoted to Professor one year later. In 2018, he joined College of Energy at Beijing University of Chemical Technology. He has more than 70 peer-viewed papers published in highly prestigious journals such as “Nature Communications, Journal of the American Chemical Society, Angewandte Chemie International Edition and Chemical Science.” His research interests include carbon nanomaterials, polymer science and electrochemical energy storage.
Abstract:
With the rapid developments in the markets of portable electronics and electric/hybrid vehicle, efficient energy storage and conversion materials with high power, high energy and long life span are urgently needed. Rational design of polymer composites is an effective approach to develop high-performance energy materials. With the unique structures and outstanding physical and chemical properties, carbon nanomaterials including graphene and carbon nanotubes are the ideal candidates for energy storage and conversion materials. In our research, we focus on the fundamental issues such as the surface modification of carbon nanomaterials, the manipulation of multi-scaled structures of the composites as well as the relationship between the structures of the composites and the performance of the energy storage and conversion devices. In our recent research, we proposed a facile in situ method for preparing three-dimensional porous graphitic carbon composites containing sulphur nanoparticles (3D S@PGC) with sulphur content up to 90 wt%. Because of the high sulphur content, the nanoscale distribution of the sulphur particles and the covalent bonding between the sulphur nanoparticles and the PGC, the 3D S@PGC cathodes exhibit high specific capacity (1382, 1242, 1115 mA h g−1 at 0.5, 1, 2 C, respectively), long cycling life (a small capacity decay of 0.039% per cycle over 1000 cycles at 2 C), excellent rate capability at a high charge/discharge current.
Danjun Fang
Nanjing Medical University, China
Title: Codetermination of sphingomyelin and cholesterol in cellular plasma membrane in sphingomyelin-depletion-induced cholesterol efflux
Biography:
Danjun Fang，Zhejiang University of Technology, BE, Analytical Chemistry (1997/9 - 2001/6). 2001/9 - 2004/6，Zhejiang University, Master, Chemistry. 2004/8 - 2010/1，Case western reserve university, PhD, Chemistry. 2010/5 – 2010/10, Case western reserve university, Post Doc, Chemistry. 2011/11 – present, Nanjing Medical University, Associate professor of Analytical Chemistry. Research Interests: Electro-analytical Chemistry, single cell analysis, pharmaceutical analysis.
Abstract:
Quantification of multiple lipids with different contents in plasma membrane in single cells is significant, but challenging for investigating lipid interactions and the role of dominant protein transporters. In this paper, co-monitoring the alteration of low-content sphingomyelin (SM) and high content cholesterol in plasma membrane of one living cell is realized by use of luminol electrochemiluminescence (ECL) for the first time. Concentrations of SM as low as 0.5 μM are detected, which permits the measurement of low-content membrane SM in single cells. More membrane cholesterol is observed in individual cells after depletion of membrane SM, providing direct evidence about SM depletion induced cholesterol efflux. The up-regulation of ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1) in SM depleted cells induces a further increase in membrane cholesterol. These results imply that higher expression of ABCA1/G1 promotes cholesterol trafficking, which offers additional information to solve the debate about ABC transporters in cholesterol efflux. Moreover, the established approach offers a special strategy to investigate the correlation of membrane lipids and the role of transporters in cholesterol trafficking.
Chang Ho Oh
Hanyang University, South Korea
Title: Synthetic study to icetexane natural products by using transition-metal catalysis
Time : 11:15-11:35
Biography:
Chang Ho Oh received his BS degree from Seoul National University and his MS degree from KAIST, Korea in 1982 and 1984, respectively. He obtained his PhD in 1992 under guidance of Professor Gary H Posner. After a year of Post-Doctoral study with Professor Barry M Trost at Stanford University, he became a full-time faculty member of Inje University, Korea. In September, 1997, he moved to Hanyang University, where he is currently a Professor at the Department of Chemistry. His area of research interest includes development of new and applicable synthetic methodologies using transition-metal catalysis and synthesis of natural products.
Abstract:
Numerous [m,7,n]-tricyclic structural motifs are found in a variety of icetexane natural products, many of which have a broad spectrum of biological activities. Among various strategies for the construction of seven membered carbocycles, transition metals are utilized as catalysts because of their inherent potential for causing a rapid increase in skeletal complexity. Conjugated Enynals and Enynones serve versatile substrates for the synthesis of such [m,7,n]-tricyclic skeletons via metal catalyzed reactions. They are known to form metal-pyrylium intermediates with alynophilic metals such as Au, Rh, or Pt and the resultant metal-pyrylium intermediates are also known to undergo cycloaddition with an alkene inter and/or intramolecularly (Scheme 1). During the course of our scientific endeavors leading to a general and modular entry to polycyles, we have reported a highly unique behavior of metal-carbene complexes A, formed via [3+2] cycloaddition between metal pyrylium species and a double bond, to polycycles (2-6) depending on the type of substrates, catalysts and reaction conditions.This result have been applied to the total synthesis of icetexanes and abietanes and will be presented in Euro-Chemistry 2019.