Day 1 :
University of Kentucky, USA
Keynote: Development of 3-arylquinolines as antineoplastic agents that trigger PAR-4 secretion and tumor cell apopotosis
Time : 09:00-09:25
Benemerita Universidad Autónoma de Puebla, Mexico
Keynote: Fluorescence emission color changes of acrylonitrile derivatives, structure and optical properties
Time : 09:25-09:50
María J Percino received her first degree in Chemistry at the Universidad Autónoma de Puebla, Mexico and MSc in Inorganic Chemistry at Universidad Nacional Autónoma de Mexico. Her PhD in Polymer Chemistry at Al-Farabi KazNU ex-URSS. Her area of research interest is polymerization process, synthesis of functional monomers as well as the design and crystals engineering of organic compounds to study photoluminescence, conductivity and supramolecular chemistry. She has published more than 65 papers in reputed journals.
Solid state lighting (SSL) of organic chromophores has attracted much attention due to their potential applications in devices such as light-emitting diodes, photovoltaic devices and sensors. Tuning and controlling the wavelength of emission of an organic material is crucial to identify the appropriate application and the optical properties of different dyes in the solid state and strongly depend on the molecular structure and intermolecular interactions. Recently, organic chromophores that exhibit quenching of fluorescence in the solid state have been reported and this phenomenon is termed as aggregation caused quenching (ACQ). Herein, we report results from optical characterization (absorption and emission) of a,β-unsaturated acrylonitrile with structures of electron donor D-π-A acrylonitrile derivatives. The investigation reveals differences in the characteristic emission such as an enhancement in fluorescence in solvent, as well as in the solid state. Their photophysical properties have been investigated to evaluate the effect of the substituents, which afforded a dye that exhibited emission depending of the morphology.
Loyola University Chicago, USA
Keynote: Carborane-containing Matrix Metalloproteinase (MMP) enzyme inhibitors as tumortargeting ligands for Boron Neutron Capture Therapy (BNCT)
Time : 09:50-10:15
Daniel Becker earned his PhD at Indiana University in Bloomington, Indiana and worked in the pharmaceutical industry in Searle, Pharmacia and then Pfizer as a Project Leader and Research Fellow in cancer, arthritis, and cardiovascular diseases. He moved from industry and joined Loyola University Chicago in 2004 where he serves as a Full Professor of Chemistry performing research in synthetic organic and medicinal chemistry, especially in antibiotics and in cancer, as well as in supramolecular chemistry. He has published more than 50 scientific papers in various areas of chemistry and is an inventor on over 50 U.S. patents
Boron neutron capture therapy (BNCT) is a non-invasive modality of treating brain tumors as well as head and neck tumors through delivery of a molecule containing 10B atoms to the tumor, which absorb a neutron under low-energy neutron irradiation to yield unstable 11B nuclei that undergo fission to yield high energy alpha particles (4He nuclei) and high energy lithium-7 (7Li) nuclei that are limited in range to 5–9 µm, approximately the diameter of the target cell. The challenge for improving BNCT is to target tumor cells to enable selective and efficient delivery of the 10B atoms. Recognizing that matrix metalloproteinase (MMP) enzymes, especially gelatinases MMP-2 and MMP-2, as well as collagenase MMP-13, are upregulated in tumor cells, we selected to incorporate carborane clusters into scaffolds that are known to bind potently and selectively to these MMP enzymes. Diaryl ether sulfone hydroxamate MMP inhibitors have served as clinical candidates for cancer treatment, and bear a piperidine substituent that is known to project from the MMP active site into solvent when the molecules are bound to MMP enzyme, thus enabling attachment of even very large dyes for imaging of tumors. Hence we have installed boron-rich carborane clusters to the piperidines nitrogen utilizing Click chemistry for attachement of the carborane moiety. Herein we report the successful multistep synthesis of these BNCT agents and the potent MMP enzyme inhibition by these molecules as we proceed toward in vivo efficacy testing.
University of Liverpool, UK
Time : 10:15-10:40
Tamoghna Mitra has completed his PhD from Universität Bielefeld 2009 on a topic of polyoxometalate cluster and worked with professor Andrew I Cooper on organic porous materials and has published 19 papers in reputed journals on this topic.
Porous materials are an important class of compounds. Porous materials, such as terracotta, charcoal and dried plant husks, have been used for millennia for filtration and purification. In modern times, porous materials such as zeolites have found extensive use in separation processes such as petrochemical cracking, ion-exchange and the separation and extraction of gases and solvents. Other synthetic porous materials like Metal-Organic-Framework (MOF), Covalent-Organic Framework (COF) have emerged as important materials for separations. Porosity in these materials emerges as extended solids in which the molecular building blocks are linked together by strong covalent bonds. In contrast, porosity in molecular crystal emerges as consequences of either inefficient packing of an awkwardly shaped molecule or the molecule have an intrinsic cavity in the molecule. What set these porous molecules apart from extended frameworks is that they are solution processable and their intrinsic cavity can be engineered. These unique features allow the use of these materials for shape and size selectivity separations. Using this strategy we have demonstrated that we can isolate isomers of organic feed stocks (such as mesitylene and other C-9 isomers, hexane isomers etc.), rare gases, chiral molecules and CO2 and N2 for the post-combustion separation process. In this talk, author would focus on selected examples that have been achieved in Liverpool to introduce broader concepts to the audience who are new to this field.