Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 9th European Chemistry Congress | Golden Tulip Berlin- Hotel Hamburg | Berlin, Germany.

Day 1 :

OMICS International Euro Chemistry 2019 International Conference Keynote Speaker Vitaliy M Sviripa photo
Biography:

Vitaliy Sviripa obtained his PhD from Institute of Organic Chemistry, Kyiv, Ukraine and completed Postdoctoral studies at the University of Kentucky (USA) in DS Watt’s laboratory. He was promoted to Research Assistant Professor at the University of Kentucky, College of Pharmacy in 2017. He has published more than 30 papers in peer-reviewed journals and he is co-inventor on numerous patents. His research interests are focused on the design, synthesis and optimization of small-molecule probes with particular emphasis on the developing antineoplastic agents that affect novel biological targets.

Abstract:

Various cancer cells often develop resistance to chemotherapy and radiation therapy, leading ultimately to the death of the patients. Therapy resistant cancer cells are susceptible, however, to apoptosis by the pro-apoptotic tumor suppressor Prostate Apoptosis Response-4 (Par-4). Par-4 is secreted by normal cells and selectively induces apoptosis in cancer cells by binding specifically to a cell-surface receptor, Glucose regulated protein-78 (GRP78) that is found only on the surface of cancer cells. Because the baseline levels of Par-4 secreted by normal cells are generally inadequate to cause apoptosis in cancer cells, secretagogues that bolster the release of Par-4 constitute an important therapeutic advance. We report a discovery and structure activity study on 3-arylquinolines or “arylquins” that induce normal cells to produce robust secretion of Par-4 protein that targets cancer cells in a paracrine manner. We identified 3-arylquinoline derivative, designated as Arylquin 1, as a potent Par-4 secretagogue that inhibits the proliferation of various cancer cells in vitro at nanomolar levels and in vivo in mice. Arylquin 1 induced a dose-dependent apoptosis in cancer cells without affecting normal cells. Using a biotinylated analog, we identified vimentin, a cytoskeletal intermediate filament protein, as its principal target. Arylquin 1 binds vimentin and displaces the Par-4 protein that acts as a tumor suppressor and kills cancer cells while leaving normal cells unharmed. Because, vimentin is also a key component of the epithelial mesenchymal transition (EMT) necessary for metastasis in diverse cancers, the identification of vimentin as the target for arylquins is consistent with arylquins functioning as antineoplastic agents.

Keynote Forum

Maria J Percino

Benemerita Universidad Autónoma de Puebla, Mexico

Keynote: Fluorescence emission color changes of acrylonitrile derivatives, structure and optical properties

Time : 09:25-09:50

OMICS International Euro Chemistry 2019 International Conference Keynote Speaker Maria J Percino photo
Biography:

María J Percino received her first degree in Chemistry at the Universidad Autónoma de Puebla, Mexico and MSc in Inorganic Chemistry at Universidad Nacional Autónoma de Mexico. Her PhD in Polymer Chemistry at Al-Farabi KazNU ex-URSS. Her area of research interest is polymerization process, synthesis of functional monomers as well as the design and crystals engineering of organic compounds to study photoluminescence, conductivity and supramolecular chemistry. She has published more than 65 papers in reputed journals.

 

Abstract:

Solid state lighting (SSL) of organic chromophores has attracted much attention due to their potential applications in devices such as light-emitting diodes, photovoltaic devices and sensors. Tuning and controlling the wavelength of emission of an organic material is crucial to identify the appropriate application and the optical properties of different dyes in the solid state and strongly depend on the molecular structure and intermolecular interactions. Recently, organic chromophores that exhibit quenching of fluorescence in the solid state have been reported and this phenomenon is termed as aggregation caused quenching (ACQ). Herein, we report results from optical characterization (absorption and emission) of a,β-unsaturated acrylonitrile with structures of electron donor D-π-A acrylonitrile derivatives. The investigation reveals differences in the characteristic emission such as an enhancement in fluorescence in solvent, as well as in the solid state. Their photophysical properties have been investigated to evaluate the effect of the substituents, which afforded a dye that exhibited emission depending of the morphology.

 

OMICS International Euro Chemistry 2019 International Conference Keynote Speaker Daniel P Becker photo
Biography:

Daniel Becker earned his PhD at Indiana University in Bloomington, Indiana and worked in the pharmaceutical industry in Searle, Pharmacia and then Pfizer as a Project Leader and Research Fellow in cancer, arthritis, and cardiovascular diseases. He moved from industry and joined Loyola University Chicago in 2004 where he serves as a Full Professor of Chemistry performing research in synthetic organic and medicinal chemistry, especially in antibiotics and in cancer, as well as in supramolecular chemistry. He has published more than 50 scientific papers in various areas of chemistry and is an inventor on over 50 U.S. patents

Abstract:

Boron neutron capture therapy (BNCT) is a non-invasive modality of treating brain tumors as well as head and neck tumors through delivery of a molecule containing 10B atoms to the tumor, which absorb a neutron under low-energy neutron irradiation to yield unstable 11B nuclei that undergo fission to yield high energy alpha particles (4He nuclei) and high energy lithium-7 (7Li) nuclei that are limited in range to 5–9 µm, approximately the diameter of the target cell.  The challenge for improving BNCT is to target tumor cells to enable selective and efficient delivery of the 10B atoms.  Recognizing that matrix metalloproteinase (MMP) enzymes, especially gelatinases MMP-2 and MMP-2, as well as collagenase MMP-13, are upregulated in tumor cells, we selected to incorporate carborane clusters into scaffolds that are known to bind potently and selectively to these MMP enzymes.  Diaryl ether sulfone hydroxamate MMP inhibitors have served as clinical candidates for cancer treatment, and bear a piperidine substituent that is known to project from the MMP active site into solvent when the molecules are bound to MMP enzyme, thus enabling attachment of even very large dyes for imaging of tumors. Hence we have installed boron-rich carborane clusters to the piperidines nitrogen utilizing Click chemistry for attachement of the carborane moiety.  Herein we report the successful multistep synthesis of these BNCT agents and the potent MMP enzyme inhibition by these molecules as we proceed toward in vivo efficacy testing.

 

Keynote Forum

Tamoghna Mitra

University of Liverpool, UK

Keynote: Porous organic molecular solids for separation

Time : 10:15-10:40

OMICS International Euro Chemistry 2019 International Conference Keynote Speaker Tamoghna Mitra photo
Biography:

Tamoghna Mitra has completed his PhD from Universität Bielefeld 2009 on a topic of polyoxometalate cluster and worked with professor Andrew I Cooper on organic porous materials and has published 19 papers in reputed journals on this topic.

 

Abstract:

Porous materials are an important class of compounds. Porous materials, such as terracotta, charcoal and dried plant husks, have been used for millennia for filtration and purification. In modern times, porous           materials such  as zeolites have found extensive use       in separation processes such    as petrochemical cracking, ion-exchange and the separation and extraction of gases and solvents. Other synthetic porous materials like Metal-Organic-Framework (MOF), Covalent-Organic Framework (COF) have emerged as important materials for separations. Porosity in these materials emerges as extended solids in which the molecular building blocks are linked together by strong covalent bonds. In contrast, porosity in molecular crystal emerges as consequences of either inefficient packing of an awkwardly shaped molecule or the molecule have an intrinsic cavity in the molecule. What set these porous molecules apart from extended frameworks is that they are solution processable and their intrinsic cavity can be engineered. These unique features allow the use of these materials for shape and size selectivity separations. Using this strategy we have demonstrated that we can isolate isomers of organic feed stocks (such as mesitylene and other C-9 isomers, hexane isomers etc.), rare gases, chiral molecules and CO2 and N2 for the post-combustion separation process. In this talk, author would focus on selected examples that have been achieved in Liverpool to introduce broader concepts to the audience who are new to this field.